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Future multi-center clinical trials that incorporate various imaging modalities and stratify participants by various factors, such as age of onset and disease stage, will provide a more comprehensive understanding of FRDA and contribute to the development of new therapies

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Clinically, these mechanisms emphasize the potential value of combining DOX with autophagy inhibitors, lysosomal function modulators, or regulators of lipid raft integrity to overcome resistance

TLRs are also involved in promoting functional DNA repair, repairing DNA damage caused by UVB radiation, and stimulating TLR2,3,4,7,8, and 9