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Published validation flags REM as its weakest stage (21-min discrepancy vs PSG)

J Am Soc Nephrol 21: 622-633, 2010 can be adapted to the CRISRP-Cas system of the present invention and a dose of about of 10-20 pmol CRISPR Cas complexed with nanocarriers in about 1-2 liters of a physiologic fluid for i.p

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