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From these metrics, participants were stratified into four clinical groups: neuropathological AD diagnosis with dementia (dementia, 25 participants), neuropathological AD diagnosis without dementia (resilient, 25 participants), no AD or other neurological disease diagnosis with dementia (frail, 26 participants), and a control group with no AD or other neurological disease diagnosis and negligible cognitive decline at time of death (control, 26 participants)

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Any references to age-related changes or tissue-associated signaling are provided only as research context and do not imply human or animal use