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Therefore, iron deficiency, due to inadequate dietary intake or malabsorption, can impair thyroid hormone synthesis and secretion, increasing the risk of thyroid diseases [16, 54, 55]

doi: 10.3389/fendo.2019.00777 Received 01 July 2019 Accepted 24 October 2019 Published 12 November 2019 Volume 10 - 2019 Edited by David Gregory Mottershead, Keele University, United Kingdom Reviewed by Briony Forbes, Flinders University, Australia

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Mitochondrial metabolism is directly linked to 5FU sensitivity Clinically, patients with CRC usually undergo 612 cycles of 5FU-based or fluoropyrimidine-based chemotherapy 2,41