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Studies have shown that systemic OGP administration increases bone formation rate and trabecular bone volume in intact animals and accelerates fracture healing in models of skeletal injury

Growth hormone treatment of abdominally obese men reduces abdominal fat mass, improves glucose and lipoprotein metabolism, and reduces diastolic blood pressure

Current preclinical literature is divergent because many studies report short follow-up intervals and lack systematic measurement of long-term endpoints such as monthly biodistribution, microglial phenotyping (for example Iba1, CD68, MHC-II), cytokine panels, neuronal loss, and behavior

Additionally, differential gene expression patterns were observed in human retinal cell cybrids containing mitochondria from AMD patients compared to those from age-matched normal subjects (Nashine et al., 2019)