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Jaundice is considered as one of the most common disease conditions in Nepal and its association with viral hepatitis

According to the National Institutes of Health (NIH), the human copper-binding peptide GHK-Cu (glycyl-l-histidyl-l-lysine) is a small, naturally occurring tri-peptide present in human plasma that also can be released from tissues in case of an injury

Such a phenomenon is reported before in insects such as Spodoptera litura and Helicoverpa armigera , where the enzyme upregulation crosstalk happened between GSTs and CXEs after the insecticide treatment 74 , suggesting an alternative explanation to the increase in the activity of CXEs, i.e., inhibition of the GSTs by Mg-Chl leads to increasing the oxidative stress signals inside the cells, by which the CXEs are upregulated instead of the direct interaction between CXEs and Mg-Chl

Structural abnormalities may also cause hip labral tear