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Our observations are consistent with a previous clinical study in solid tumors where continuous infusion of BSO depleted tumor GSH below 10% of pretreatment levels with minimal systemic toxic effects

The results demonstrated that compound 94 significantly inhibited the twisting reactions of mice during acetic acid-induced writhing tests, achieving a suppression rate of 78.8%

Figure 2C highlights the immunological arm of this axis, showing how SCFAs and related metabolites polarize macrophages toward an M2-like phenotype, promote Treg differentiation and increase IL-10/TGF- production, thereby dampening systemic and islet inflammation and indirectly preserving -cell function