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Specifically, these pulmonary insults lead to increased levels of LPS and DAMPs (e.g., HMGB1), which, upon binding to and activating TLR4, promote proinflammatory cytokine expression via the NF-B and MAPK pathways

KPV and Longevity One of the most exciting areas of peptide medicine is targeting chronic inflammation, often called inflammaging. Inflammaging is associated with: Biological aging Cardiovascular disease Cognitive decline Sarcopenia Metabolic disease By helping regulate inflammatory pathways, KPV may eventually become part of future longevity-focused therapeutic strategies

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Cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy in patients with advanced ovarian cancer (OVHIPEC-1): final survival analysis of a randomised, controlled, phase 3 trial