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A recent study shows that upregulation of Nrf2 gene expression in a mice experiment led to increased NQO-1 protein content and activity, as well as elevated HO-1 protein content and activity in the brain, while in the liver, HO-1 activity and mRNA levels, NQO-1 activity, and protein content were augmented (92).This study reveals the tissue-specific regulation of Nrf2 signaling and downstream antioxidant enzymes in the mice, highlighting its adaptive response to varying oxygen concentrations

Hence, the authors are concluding that it's worth it to conduct trials in humans (Valizadeh et al., 2021)

We may also combine glutathione with Vitamin C or other nutrient boosters to enhance its skin-brightening and antioxidant effects

You can boost your glutathione levels through a diet rich in sulfur-containing foods, regular exercise, stress management, and quality supplementation