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You should only increase your dose (titrate) when: You have successfully tolerated the current dose for at least 1-2 weeks

Weeks 1-4: Foundation phase The first month establishes tolerance and begins the cellular changes that eventually produce visible results

Indeed, aptamers, with their high target specificity and affinity, emerge as a promising alternative to antibodies

Other mechanisms include increased insulin resistance induced by high-dose glucocorticoids that increases intra-portal insulin, decreases IGFBP-1 that increases free IGF-I, and direct glucocorticoid effects in increasing hepatic IGF-I synthesis and decreasing hepatic insulin clearance (105)