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NAC significantly reduced markers like morning stiffness, disease activity score, nitric oxide, fasting blood sugar, and increased HDL cholesterol, although not all improvements were significantly different from the placebo group

What might be the reason for this initial decline in well-being

The prevailing medical advice emphasises informed decision-making, individualised assessment, and appropriate monitoring rather than blanket approval or prohibition

We also highlight emerging opportunities such as new ferroptosis-inducing agents, biomarker-guided patient selection and rational combinations with chemotherapy, radiotherapy, targeted agents or immunotherapies