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Nutrients, 2017

Ex-117b 1 H NMR (600 MHz, Chloroform-d) 7.85 (d, J=9.5 Hz, 1H), 7.37 (t, J=7.9 Hz, 1H), 7.12 (d, J=7.9 Hz, 1H), 6.99 (d, J=12.0 Hz, 1H), 6.58 (t, J=73.9 Hz, 1H), 4.38-4.23 (m, 1H), 4.10 (d, J=10.2 Hz, 2H), 3.84 (dd, J=58.6, 13.8 Hz, 1H), 3.50 (p, J=12.7, 12.0 Hz, 2H), 3.34 (dq, J=59.8, 11.5, 11.1 Hz, 1H), 3.21 (td, J=15.5, 10.3 Hz, 2H), 3.15-3.02 (m, 2H), 3.02-2.97 (m, 1H), 2.71 (dq, J=34.5, 15.5, 15.0 Hz, 3H), 2.47-2.24 (m, 2H), 2.14 (p, J=12.2 Hz, 1H), 1.87 (t, J=14.0 Hz, 2H), 1.58 (d, J=4.9 Hz, 3H)

These SASP components activate multiple signaling cascades, including the NF-B pathway, in neighboring cells, thereby propagating senescence and creating a pro-inflammatory microenvironment conducive to age-related pathologies[63]

rather, it participates systemically in the maintenance of lipid metabolic homeostasis through coordinated regulation across multiple signaling pathways and organ systems