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Further evidence by Wang et al

Concentrations were calculated using a subsequent four-parameter logistic regression based on the standard analyte concentrations using GraphPad PRISM software (Dotmatics, Boston, MA, USA)

The interaction between p53 and MDM2 can be disrupted by NPM1 when NPM1 translocates from the nucleolus to nucleoplasm where NPM1 bound to MDM2 to induce p53 accumulation [19]