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In addition, subclinical intestinal inflammation has been observed in treatment nave patients with early RA as well as before the onset and during the course of arthritis in animal models, and there is evidence about an impact of inflammatory cytokines (such as tumor necrosis factor (TNF) and interferon gamma (IFN)) on the integrity of TJs by reducing the levels of occludins and ZO-1 [2, 5]

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And unless we can reduce oxidative stress from the top down, all were doing is going to different subspecialties to deal with the symptomstheyre not dealing with the root cause of the problem, he says

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