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The oxygen-binding site on CIV is comprised of a binuclear heme iron/copper center, which exists in an oxidized or reduced state depending on the surrounding oxygen concentrations ( Although it has been established that NO decreases the flow of electrons through the respiratory chain complexes, which inhibits respiration and decreases oxygen consumption (Whitfield et al., 2016)

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Common factors that lead to black circles include: Pigmentation: Under-eye dark circles can be worsened by free radicals and other factors, including radiation, sun exposure, and pollution

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