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559 Later, other researchers have used JPH203, a SLC7A5 inhibitor, to target glutamine metabolism, resulting in increased CD8 + T cell infiltration

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Briefly, there are four possible mechanisms of CRPC development: 1) Increased sensitivity of the AR to its agonists, 2) AR mutations that render the receptor responsive to alternate, non-androgen ligands, 3) ligand-independent AR activation, and 4) AR-independent mechanisms (Figure 5)