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Trastuzumab deruxtecan in previously treated HER2low advanced breast cancer

The prevalence of sarcopenia increased steeply with age, reaching 31.6% in women and 17.4% in men older than 80 years [46]

The inotropic effect is augmented by caffeines inhibition of phosphodiesterase, which increases the concentration of cAMP in the myocardium and enhances the intracellular influx of calcium ions into cardiomyocytes