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The applicant asserted that the Axoguard HA+ Nerve Protector TM demonstrates clinical improvement in: (1) nerve health in an injured tissue bed through less adhesion, extraneural scarring, and inflammatory markers, (2) nerve health in an injured tissue bed through decreased friction between the nerve and surrounding tissue to allow for gliding and to minimize potential for soft tissue attachment, (3) device performance due to its sodium hyaluronate and sodium alginate gel layer that allows for nerve gliding, and (4) sensory and motor symptoms

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Increased -catenin can initiate transcriptional activation of proteins such as cyclin D1 and c-myc , which control the G1 to S phase transition in the cell cycle