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Mol Cell Biol 29:13631374 You Y, Liang W (2023) SIRT1 and SIRT6: The role in aging-related diseases

1 Effect Allele: TC (+/-) You have the TC genotype for rs1805008, which means you carry one copy of the effect allele and one copy of the non-effect allele

For most components of these pathways in most eukaryotic systems, such as Grxs, Trxs, and TrxRs, separate genes arose by gene duplication that evolved to specialize, albeit to varying extents, in production of either cytosolic or mitochondrial isoforms of these enzymes (Gleason and Holmgren, 1981

Michael Won for extensive LCAT crystallization screening and Dr Jennifer Cash for advice and support with mammalian cell culture