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By directly downregulating SIRT1, miR-34a leads to increased synthesis of inflammatory cytokines, including IL-6, TNF-, IL-1, and IL 8, and oxidative stress proteins, including MCP-1, vascular cell adhesion protein 1 (VCAM1), and MDA, and decreased levels of the anti-inflammatory cytokine IL-10 [297, 303]

Supplementary information Supplementary Figures 13 and Supplementary Tables 13 (PDF 743 kb) Rights and permissions About this article Cite this article Mason, R., Casu, M., Butler, N