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The toxicity of intramuscularly administered rotigotine behenate-loaded PLGA microspheres (rotigotine loading of 22.527%) was evaluated over a 20-week period in Sprague Dawley (107 males and 107 females) rats which received 5 doses of rotigotine behenate-loaded PLGA every 28 days at different doses 60, 180, and 540 mg/kg (calculated as rotigotine) 137

They give tall sums of biotin, zinc, press, folate, and antioxidants

In animal models of neurodegenerative disease, activation of TGR5 receptor was neuroprotective, decreasing neuronal death and inflammatory response (Monteiro-Cardoso et al., 2021)