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Several studies reported that SP displayed protective effects in rats liver and kidney against toxicities through upregulation of the SIRT1 expression 28,29

It has the advantages of simple operation, low cost, repeatability and low mortality, but the disadvantage is that it is time-consuming

Some studies have identified changes in the gut microbiota as a potential factor in the pathophysiology of obesity and asthma

For example, taking very high doses of vitamin B6 can lead to potentially irreversible nerve damage over time, while taking large amounts of niacin typically in excess of 2 grams per day can cause liver damage ( Fat-soluble vitamins Unlike water-soluble vitamins, fat-soluble vitamins do not dissolve in water and are easily stored in your bodys tissues ( There are four fat-soluble vitamins: Vitamin A Vitamin D Vitamin E Vitamin K Given that fat-soluble vitamins can accumulate in the body, these nutrients are more likely to lead to toxicity than water-soluble vitamins