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In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid (MPTP/P)-induced Parkinsons disease model mice, MPTP/P injection increased the ratio of Bax/Bcl-2 and the expression of caspase-3 in the hippocampus, while berberine administration reversed these effects (Kim et al., 2014)

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Still, Nrf2-deficient mice display age-dependent cardiomyopathy (87)

In particular, chromatin immunoprecipitation followed by sequencing (ChIPseq) has generated vast amounts of data on the genome-wide distribution of histone modifications across various cell types