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Alterations in amino acid metabolism have been associated with mitochondrial dysfunction as well as underlying diseases such as cancer and fetal growth restriction syndrome

one or more chemical entities e.g., nicotinamide riboside, nicotinamide mononucleotide the invention encompasses a method of providing muscular therapy by contacting a cell expressing NNMT with a NNMT inhibitor (such as a cation of Formula I or IA, or otherwise disclosed herein) and one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that modulates intracellular NAD+ levels to provide muscular therapy

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The doctor will determine the correct dosage, frequency of administration and duration of treatment, taking into account the individual condition of each patient