glutathione s transferase p S-transferase π: a potential role in antitumor therapy | DDDT Pleiotropic Functions of Glutathione S-Transferase

Cell (2017) This landmark Cell publication from Erasmus University Medical Center introduced FOXO4-DRI as a senolytic peptide that selectively eliminates senescent cells by disrupting the FOXO4-p53 interaction

Interestingly, selenium deficiency in rodents was found to have little impact on DIO activities as it appears that selenium is being supplied in priority for adequate synthesis of DIOs at the expense of other selenoenzymes (10)

Other considerations for senolytic trials include optimal dosage and delivery scheme for maximum healthspan benefits

It assists in the breakdown of fats and aids in the synthesis of cholesterol, red blood cells, and glycogen