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Fluorescent lineage tracing in zebrafish has enabled precise tracking of metastatic processes, including vascular migration and micrometastatic colonization (113)

In terms of fundamental research, the dysregulation of Beclin-1 has been extensively documented in numerous studies

This strategy not only improves the therapeutic index but also significantly reduces toxicity to healthy cells, making it a core technology in modern ADC design

Specifically, EMAP II significantly upregulated the expression of miR-429, which not only inhibited the expression of ZO-1 and occludin by directly interacting with them, but also reduced the expression of TJ-related proteins by downregulating the expression and phosphorylation of p70 ribosomal protein S6 kinase (p70S6K)