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To deal with the extra ROS, mitochondria developed an antioxidant system to counteract the massive buildup of ROS and avoid oxidative stress

Cancer Sci 106:635641

These results provide further evidence that the elimination of intracellular Ca 2+ prevents apoptosis induced by H 2 O 2 in Prx II-knockdown HaCaT cells

Trehalose decreases mutant SOD1 expression and alleviates motor deficiency in early but not end-stage amyotrophic lateral sclerosis in a SOD1-G93A mouse model