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But adjunct therapy on top of a sub-optimal foundation is unlikely to produce the result the patient is looking for, and can produce confusion about what is and is not working

Similarly, imatinib alone increased tumor hypoxia in control tumors but no effect on FGF-2 + tumors (Fig

However, the lack of drug-like characteristics, such as poor target specificity and selectivity, high toxicity, several off-targets, severe side effects, poor metabolic stability, poor membrane permeability and rapid proteolysis, make this molecule fairly unsuitable candidates for therapeutic applications

For bruised ribs or minor injuries, 4-6 weeks may suffice