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Murine studies show no acute toxicity at doses up to 100 mg/kg, and the Nature Metabolism paper reported no adverse metabolic effects during the 11-week treatment period

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The definitive 24-week Phase III trial in 534 obese participants, testing doses of 0.25mg, 0.5mg and 1.0mg daily, did not produce statistically significant weight loss over placebo

Understanding the cellular phenotype and heterogeneity of cancers prior to the initiation of cancer treatment is critical, as is monitoring response to therapy during its course [98]