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Future efforts should therefore concentrate on identifying potent, selective GR inhibitors, elucidating their mechanisms, and affirming their effectiveness and safety in preclinical studies

Pharmacol., vol

(71) provided a comprehensive overview of various colon-targeted delivery systems, including resistant starch and natural biopolymers, emphasizing their shared mechanism of action: bypassing enzymatic degradation in the upper gastrointestinal tract and undergoing microbial enzyme-triggered breakdown in the colon to release bioactive compounds

The significance of differences was assessed using either an unpaired t-test or one-way analysis of variance (ANOVA), and p -values less than 0.05 or 0.01 were considered statistically significant