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Prominent features include subchondral bone cysts, also known as intraosseous lesions, that form in regions subjected to repetitive mechanical overload

In the skin, vitamin C plays a critical role in synthesizing collagen, the protein that provides structure and elasticity

Se, through GSH reductase and other selenoproteins, regulates the antioxidant activity in cells, thus protecting the human body against harmful effect of free radicals and, conse- quently, reducing the risk of cancer [ 47 , 48 ]

Cystathionine--synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation