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The CES-D-8 was introduced in the TILDA study at waves 2 and 3, and a score of 9 on this scale was used to define clinically significant depressive symptoms at these waves (Reference Briggs, Carey and Kenny32,Reference OHalloran, Kenny and King-Kallimanis33)

Patients undergoing PRP therapy have shown gradual and everlasting reductions in pain, along with better tolerance to normal activities such as brushing teeth or speaking

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Immunofluorescence staining was performed to assess macrophage polarization, with CD86 serving as a marker for pro-inflammatory M1 macrophages and CD206 for anti-inflammatory M2 macrophages