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Opioid receptors can inhibit multiple levels of the ascending pain pathways for pain signal transmission in supraspinal regions related to nociceptive message integration and participate in facilitatory and inhibitory descending pathways [13,38,39]

Muralisankar M, Sujith S, Bhuvanesh NSP, Sreekanth A (2016) Synthesis and crystal structure of new monometallic and bimetallic copper(II) complexes with N-substituted isatin thiosemicarbazone ligands: effects of the complexes on DNA/protein-binding property, DNA cleavage study and in vitro anticancer activity

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demonstrated that activation of the nuclear receptor FXR by BAs significantly suppresses ferroptosis by upregulating multiple ferroptosis gatekeepers, including GPX4, FSP1, PPAR, SCD1 and ACSL3 ( Furthermore, studies have confirmed the presence of physiologically relevant concentrations of BAs species in ovarian tissue, along with expression of FXR and BAs transporters ( 4.2.4 Lactic acid bacteria metabolites Lactic acid bacteria produce various metabolites, including 1,3-diaminopropane (DAP), reuterin, and 5-methoxyindoleacetic acid (5-MIAA)