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Caspase-9 inhibition confers stronger neuronal and vascular protection compared to VEGF neutralization in a mouse model of retinal vein occlusion

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In terms of NLRP3 inhibitors, tranilast, a clinically approved anti-allergic drug with additional anti-inflammatory effects inhibiting NLRP3 inflammasome activation by disrupting the mammalian NIMA-related kinase 7 (NEK7) interaction, 224,225 has been confirmed to exhibit significant preventive and therapeutic efficacy in mouse models of NLRP3 inflammasome-mediated human pathologies, e.g., gouty arthritis and type 2 diabetes