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Laboratory studies demonstrate that ES2 peptides show 3-7 times more potent senolytic activity than FOXO4-DRI in both in vitro and in vivo experimental systems, while CPP-CAND demonstrates approximately 1.2-fold higher selectivity despite shorter peptide length

The intratumoral treatment with BCG in WT mice promoted the increment of several immune cells in the TME, such as CD4 + T lymphocytes ( Figure 4C ), CD8 + T lymphocytes ( Figure 4D ), NK ( Figure 4E ), NKT cells ( Figure 4F ), neutrophils ( Figure 4G ), dendritic cells ( Figure 4H ), and macrophages ( Figure 4I )

As we age, collagen production naturally declines, leading to wrinkles, joint discomfort, and loss of skin elasticity