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This mitochondrial connection to a wide variety of diseases positions mitotherapy to be a currently relevant topic with potentially revolutionary effects in treating these diseases of high prevalence (Roushandeh et al., 2019)

Hypertension contributes to atherosclerosis through endothelial dysfunction as well as a hyperactivation of the renin-angiotensin-aldosterone system (RAAS) and the sympathetic nervous system (SNS) (Zaheer et al., 2016)

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circRNAs also participate in a wide range of biological processes, including fibrosis, cell apoptosis, proliferation, differentiation and angiogenesis (167)