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Some studies suggest that vitamin B12 may influence bacterial activity on the skin, which can play a role in the development of acne

The estimated bioavailability of vitamin B12 from food varies because absorption decreases drastically when the capacity of the carrier to absorb and use vitamin B12 (intrinsic factor) is exceeded

The molecule was developed by the Australian pharmaceutical company Metabolic Pharmaceuticals (in collaboration with Monash University) and advanced through Phase I safety trials and a Phase IIb obesity efficacy trial enrolling approximately 900 participants in total

Taking B12 with food, switching to a different formulation, or trying a liquid preparation may reduce nausea