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Anti-TNF- agents (infliximab, adalimumab) remain first-line options, significantly reducing intestinal inflammation by blocking TNF-

Nat Immunol 12(3):213221 Ambruso DR, Knall C, Abell AN, Panepinto J, Kurkchubasche A, Thurman G, Gonzalez-Aller C, Hiester A, deBoer M, Harbeck RJ, Oyer R, Johnson GL, Roos D (2000) Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation

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Collectively, the interrelationships among various RCD pathways are complex and tightly knit, forming an interactive network that regulates cell death and immune responses