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Hydrocodone bitartrate and acetaminophen tablet-treated patients with significant chronic obstructive pulmonary disease or cor pulmonale, and those with a substantially decreased respiratory reserve, hypoxia, hypercapnia, or pre-existing respiratory depression are at increased risk of decreased respiratory drive including apnea, even at recommended dosages of hydrocodone bitartrate and acetaminophen tablets [see WARNINGS, Life-Threatening Respiratory Depression]

Blood Clots Men with existing clotting disorders face an elevated DVT/PE risk with hCG based on its impact on coagulation factors

[] Although there are several ingredients with A level of evidence, their use should be considered with caution

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