Lipoxin A4 upregulates the expressions of GPX4, lysophosphatidic acid receptor-3, and estrogen receptor beta in FLSs, decreases the expression of MMP13 and MMP3, improves the pain performance of OA rats, and alleviates the synovial and cartilage lesions of OA rats by inhibiting ferroptosis
201 Additionally, in response to HFD intake, IL-6-mediated inflammation has been shown to accelerate prostate cancer tumor growth and increase the fraction of MDSCs and the M2/M1 macrophage ratio
Glossary 5-ASA 5-aminosalicylic acid UC ulcerative colitis TCM traditional Chinese medicine NF-B nuclear factor kappa-light-chain-enhancer of activated B cells MAPK mitogen-activated protein kinase ERK extracellular signal-regulated kinase TNF- tumor necrosis factor-alpha IL interleukin (e.g., IL-1, IL-4, IL-6, IL-8, IL-10) CRP C-reactive protein Hs-CRP high-sensitivity C-reactive protein DAI disease activity index MHC-II major histocompatibility complex class II STAT signal transducer and activator of transcription (e.g., STAT3, STAT6) Th T helper cell (e.g., Th1, Th2) CB cannabinoid receptor (e.g., CB1, CB2) GPR35 G protein-coupled receptor 35 sIgA secretory immunoglobulin A SCFAs short-chain fatty acids MUC-2 mucin 2 ZO-1 zonula occludens-1 TLR Toll-like receptor MDA malondialdehyde SOD superoxide dismutase GPx glutathione peroxidase GSH glutathione ROS reactive oxygen species MPO myeloperoxidase LPS lipopolysaccharide MMP-9 matrix metalloproteinase-9 eNOS endothelial nitric oxide synthase VEGF vascular endothelial growth factor PLT platelets MPV mean platelet volume IPA indole-3-propionic acid IAA indole-3-acetic acid AhR aryl hydrocarbon receptor PXR pregnane X receptor BDNF brain-derived neurotrophic factor TrkB tropomyosin receptor kinase B p75NTR p75 neurotrophin receptor RCT randomized controlled trial GI gastrointestinal References 1 Ahmed NajarI.SharmaA.AlshammariA.AlbekairiT
Big week for peptides
