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AAV-mediated gene therapy for AIP utilizing recombinant AAV8-based serotype vector encoding murine HMBS (rAAV2/8- HMBS ) under the liver-specific transcriptional control of a hepatocyte enhancer and promoter has been tested in mice with AIP

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These concepts, outlined in Figure 1, are relevant for our discussion

GSH reducido y GSSG oxidado En el cuerpo, el glutatin existe principalmente en dos formas interconvertibles: glutatin reducido (GSH) y glutatin oxidado (GSSG), y el equilibrio entre estas formas refleja el estado redox celular