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This protective role helps maintain cellular integrity and reduces the risk of chronic diseases associated with oxidative damage

Antioxidant supplementation is one of the most widely studied and applied approaches to enhancing sperm antioxidant defenses

Biochemical analyses indicated that THPE2-F has promise as a therapeutic agent for DR, given its capacity to restore GSH levels and to regulate iron levels under hyperglycemic conditions in DR mice (147)

Further emphasizing their role as signaling molecules, ROS and particularly H 2 O 2 , are also major regulators of gene expression, as evidenced by extensive genome expression reprogramming under conditions promoting H 2 O 2 accumulation (Queval et al., 2007