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In tumor cells, vitamin C often acts as a pro-oxidant due to high metal ion concentrations in the cytoplasm of the cell (such as Fe2+), which leads to oxidative stress due to reactions such as the Fenton reaction

Pugazhenthi S, Qin LM, Bouchard R (2015) Dipeptidyl peptidase-4 inhibition in diabetic rats leads to activation of the transcription factor CREB in -cells