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Lenti MS2-P65-HSF1_Hygro was a gift from Feng Zhang

Compared with the wild-type (WT) GPCR activation, the common pharmacological mechanisms of activating and inactivating mutations lie in three aspects: (1) Mutations transform micro-switch cascades within the receptors and induce active/inactive conformations, thus altering the constitutive activity of GPCRs and affecting the recruitment of downstream effectors

Gene expression regulation, particularly in metabolic and enzymatic research models.Mitochondrial ATP production pathways, supporting metabolic efficiency and energy-related cellular studies

Sotolongo et al., 2020)