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Training circadian clocks for cancer treatment Based on the rhythm entrainment mechanism by photic stimuli, morning bright light (MBL) exposure has been widely implemented to cure sleep problems (e.g., advanced or delayed sleep phase syndromes), neuropsychiatric diseases (e.g., autism spectrum disorder, attention deficit hyperactivity disorder, and dementia), and metabolic disorders (e.g., diabetes and obesity) in preclinical or clinical settings 52

Song Y, Zhan G, Zhou SF

In common, physical or psychological stresses cause stress and disrupt homeostasis

ER stress, particularly through the PERK-eIF2-ATF4 pathway which leads to increased levels of CHOP, can contribute to ferroptosis