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These gaps underscore the need for more rigorous approaches, including gene-editing technologies, multi-omics analysis, and in vitro and in vivo models to elucidate the molecular mechanisms by which natural products may regulate autophagy and to assess their potential translational relevance in ovarian function preservation

Moreover, Small partly non-controlled clinical pilot studies have explored the efficacy of ketogenic diets in alleviating fatigue symptoms associated with multiple sclerosis, Parkinsons disease, and the impact of short-term fasting on cancer-related fatigue [106,107,108]

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Given a reduction in both GPx3 and a likely reduction of glutathione production, as has been theorized by others in the field of konzo 13 , the role of oxidative damage and mitigation as a contributing factor of disease susceptibility or severity is only further bolstered by the findings of this study