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These data demonstrate that there may be some regulators as potential molecular links between UA homeostasis and neurodegenerative disorders

Takeda T, Okuyama H, Nishizawa Y, Tomita S, Inoue M: Hypoxia inducible factor-1alpha is necessary for invasive phenotype in Vegf-deleted islet cell tumors

Marra and Svegliati-Baroni, 2018

As per the significance of this functional shift, a body of evidence suggests that CAFs differ remarkably from normal fibroblasts regarding either molecular characteristics or their capacity to support various elements of cancer progression [35]