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(5 m thick) were mounted and stained with hematoxylin and eosin for studying the histopathological changes according to Suvarna et al

1 Introduction Moderate elevations in circulating prolactin have been associated with favorable metabolic effects ( The global prevalence of overweight and obesity continues to rise and represents a major public health concern ( Several studies have demonstrated a positive association between serum prolactin levels and body mass index (BMI), suggesting a potential role for hyperprolactinemia in obesity pathophysiology ( 2 Prolactin: biological characteristics 2.1 Structure and secretion regulation Human mature prolactin is a 199-amino-acid polypeptide with an estimated molecular mass of ~23 kDa ( Prolactin-secreting cells (lactotrophs) in the anterior pituitary gland are the primary sources of prolactin synthesis and secretion

Yanagawa et al

While this research is extensive and consistently positive, the gap between animal and human studies represents both a limitation of current knowledge and an opportunity for future research