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The hypothesis of the gain of function in GCase theorizes that the mutant form of protein is recognized as misfolded, thus placing stress on mechanisms of protein degradation and interfering with -synuclein breakdown and consequent endoplasmic reticulum stress, as observed in autophagy perturbations in cells derived from patients with GBA1 -associated PD ( 2.5.2 Clinical studies Monogenic PD cases due to GBA1 loss of function and subsequent substrate accumulation have been investigated in cellular and animal models and in studies of human brains of patients with GBA1 -associated PD showing to particularly affect pars compacta of SN, putamen, cerebellum, and amygdala and frontal cortex (Moors et al., 2019)

Various molecular pathways are also involved in MTX-induced intestinal injury including JAK/STAT3/SOCS3, Nrf2/OH-1, PPAR-, and SIRT1

Asparagus is high in the flavonoid rutin, which may help reduce inflammation and strengthen blood vessels

It effectively targets dark spots, hyperpigmentation, and uneven skin tone