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Such trials should consider phenotype-stratified populationsfor example, insulin-resistant versus lean hyperandrogenic subgroupsto determine whether responses differ across the heterogeneous PCOS spectrum

Because insurance companies refuse to pay without a reason

Children are prone to developing severe headache and pseudotumor cerebri while receiving oral tretinoin

The maintenance frequency approach offers middle ground where users completing intensive initial treatment (6-12 months daily) transition to reduced frequency (2-4 times weekly) maintaining copper supplementation at lower intensity and cost while avoiding complete discontinuation allowing some benefit decline